Ie may present as an acute, rapidly progressive rightsided native valve infective endocarditis view in chinese concomitant leftsided and rightsided ie account for approximately percent of all ie cases. Infective endocarditis ie is an infection involving either native or prosthetic heart valves, the endocardial surface of the heart or any implanted intracardiac devices 1. Those criteria are useful but they do not replace the clinical judgement of the endocarditis team. The sensitivity of duke criteria can be improved by new imaging modalities mri, ct, petct that allow the diagnosis of embolic events and of cardiac involvement when ttetoe are negative or doubtful. The duke criteria for diagnosing infective endocarditis are specific. Evaluation of the duke criteria in 93 episodes of prosthetic valve. Guidelines for the management of infective endocarditis. Duke criteria for infective endocarditis inflammatory. Individual value of each of the duke criteria for the.
C the duke criteria table 1,6 based upon clinical, echocardiographic and microbiological. Ralph corey2,3 from the divisions of 1cardiology and 2infectious diseases, and departments of 3medicine and 4pediatrics, duke university. It is the dedication of healthcare workers that will lead us through this crisis. Main complications of leftsided valve ie and their management. These were originally proposed in 1994 to help establish the diagnosis of endocarditis.
Duke university medical center curriculum vitae name. Definitive infective endocarditis ie possible infective endocarditis ie. Difference between acute and subacute endocarditis. Negative predictive value of the duke criteria for infective endocarditis g. Key difference acute vs subacute endocarditis infective endocarditis is a microbial infection of the heart valves or the mural endocardium that leads to the formation of vegetations. Negative predictive value of the duke criteria for infective endocarditis. Infective endocarditis ie carries a high risk of morbidity and mortality. Suspect ie and consider the duke criteria in patients with. Acute infective endocarditis aie is a difficult disease to suspect and diagnose.
Only 5 patients 18% had symptoms related to ut infection. A diagnosis of definite infective endocarditis is given in all of the following scenarios except. Both blood cultures and echocardiography results are not easily available soon in emergency department. Epidemiology, clinical manifestations, and diagnosis view in chinese contamination in the operating room. The diagnosis of endocarditis was qualified as definite or possible according to the duke criteria 8. The duke criteria table 1,6 based upon clinical, echocardiographic and microbiological. Mobeen presents modified dukes criteria to diagnose definitively, or to suspect, or to. Sexton,2,3 nathan mick,3 richard nettles,3 vance g. The purpose of this study was to assess the value and limitations of duke criteria for the diagnosis of infective endocarditis ie.
Current clinical guidelines for the diagnosis and management of ie recommend the use of modified duke criteria. The clinical manifestations of infective endocarditis ie are variable. Duke criteria for the diagnosis of endocarditis definite. Endocarditis diagnostic criteria modified duke criteria. Ralph corey, md, joseph kisslo, md, and the duke endocarditis service with use of new duke criteria, 405 episodes of sus. Clinical criteria for possible endocarditis requires at least one major criterion and one minor criterion, or three minor criteria. Pdf although the sensitivity and specificity of the duke criteria for the diagnosis of infective endocarditis ie have been validated by. The duke criteria are a set of clinical criteria set forward for the diagnosis of infective endocarditis.
Although the sensitivity and specificity of the duke criteria for the diagnosis of infective endocarditis ie have been validated by investigators from europe and the united states, several. Tee recommended as first test in the following patients. Diagnosis of infective endocarditis was based on the duke criteria. Duke criteria can be used to assist in the diagnosisofiebutarenotasubstituteforclinicaljudgement. Non bacterial thrombotic endocarditis sterile vegetations forms in areas of turbulent flow or where damage from particular matter in blood stream in ivdu bacterial infection of thrombus develops following bacteraemic episodes sequestration of bacteria in thrombus that phagocytic cells cannot. Karius test for the diagnosis and management of endocarditis. Utilization of specific echocardiographic findings. The duke criteria for the diagnosis of endocarditis provide a systematic approach for diagnosing both native valve endocarditis nve and pve.
New criteria for diagnosis of infective endocarditis. Pdf proposed modifications to the duke criteria for the. Communityacquired staphylococcus aureus bacteriuria. Duke criteria for infective endocarditis durack dt, lukes as, bright dk. The purpose of this survey was to elaborate clinicians knowledge and opinion on relevant heart conditions as a duke minor criterion for the diagnosis of ie. Prevention the endocarditis team diagnosis definition of the terms used in the esc 2015 modified criteria for diagnosis of ie, with modifications in main principles of prevention of infective endocarditis boldface 1.
The endocarditis diagnostic duke criteria calculator evaluates both major and minor diagnostic criteria. Pathologic criteria are histological or culture confirmation ofpathologic criteria are histological or culture confirmation of vegetation or emboli. Assesment of the duke criteria for the diagnosis of infective. These images are a random sampling from a bing search on the term duke criteria for infectious endocarditis diagnosis. Duke criteria for infective endocarditis radiology. Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults. Ie disproportionately affects those with underlying structural heart disease and is increasingly associated with health care contact, particularly in patients who have intravascular prosthetic material. Assesment of the duke criteria for the diagnosis of. Endocarditis diagnostic criteria duke criteria calculator. New valvular regurgitation new partial dehiscence of prosthetic valve abscess. Objectives the purpose of this study was to assess the value and limitations of duke criteria for the diagnosis of infective endocarditis ie. Criteria, definite infective endocarditis, possible infective endocarditis, not infective endocarditis. Established in 1994 by the duke endocarditis service and revised in 2000, the duke criteria are a collection of major and minor criteria used to establish a diagnosis of infective endocarditis.
Proposed modifications to the duke criteria for the diagnosis of infective endocarditis. The duke criteria for infective endocarditis provides standardized diagnostic criteria for endocarditis. The term predisposing heart condition is used as an indication of antimicrobial prophylaxis to prevent infective endocarditis ie and as a criterion for diagnosing ie according to modified duke criteria. Infective endocarditis ie is a rare, lifethreatening disease that has longlasting effects even among patients who survive and are cured. Major criterion includes positive blood culture for typical infective endocarditis organisms, and echocardiogram with oscillating intracardiac mass. Modified dukes criteria for infective endocarditis. Methods both classifications were applied in 93 consecutive patients with. Partial oral versus intravenous antibiotic treatment of. Modified duke criteria for endocarditis university of pennsylvania. Modified dukes criteria for the diagnosis of infective endocarditis major criteria blood cultures positive for a characteristic organism or persistently positive for an unusual organism echocardiographic evidence confirming the valvular lesions new valvular regurgitation minor criteria. Pdf proposed modifications to the duke criteria for the diagnosis. Fulfilling the criteria, and a subsequently definitive diagnosis includes either having two major criteria, one major and three minor criteria, or five minor criteria. In the absence of classical features fever, cardiac murmur, and peripheral vascular stigmata the diagnosis of infective endocarditis ie may be difficult.
To diagnose ie, the modified duke criteria have beenvalidated for use in children. Modified dukes criteria for diagnosis of infective. With use of new duke criteria, 405 episodes of suspected endocarditis were previously classified as definite, possible, or rejected endocarditis. Excludes single positive cultures for coagulasenegative staphylococci and organisms that do not cause endocarditis. For adequate diagnostic sensitivity, transesophageal echocardiography is the preferred modality used in patients.
They should be considered for evaluating suspected infective endocarditis in all patients who have a prosthetic valve or cardiac implanted electronic device, and whenever echocardiography is inconclusive and clinical suspicion remains high. The diagnostic strategy proposed by durack and colleagues2 the duke criteria combined echocardiographic findings with clinical and microbiological data. The modified duke criteria are a set of clinical criteria set forward to establish the diagnosis of infective endocarditis. Modified dukes criteria to diagnose acute infective. The diagnosis of infective endocarditis may be rejected if a firm alternate diagnosis is confirmed, if infective endocarditis syndrome resolves within 4 days of antibiotic therapy, if no pathologic evidence of infective endocarditis is found at surgery or autopsy within 4 days of antibiotic therapy, or if the case does not meet possible. The diagnosis is rejected if only 2 minor criteria or less are present. University of pennsylvania health system antimicrobial use. Negative predictive value of the duke criteria for. Modified dukes criteria for diagnosis of infective endocarditis pdf. Difference between rheumatic heart disease and infective. Diagnosis and management of infective endocarditis. To assess the value of each duke criteria for the diagnosis of infective endocarditis ie. The duke diagnostic criteria are used to make a definitive diagnosis which combines the clinical, microbiologic, pathologic, and echocardiographic characteristics of a specific.
In the absence of classical features fever, cardiac murmur, and peripheral vascular stigmata the diagnosis of infective endocarditis ie may be. Echocardiogram supportive of infective endocarditis. Backgroundsince publication of the duke criteria for diagnosing endocarditis, several articles have confirmed their sensitivity when native and prosthetic valve. Difference between acute and subacute endocarditis key. Although duke criteria have expected 80% sensitivity and specificity for the diagnosis of infective endocarditis 4, it depends mainly on the basis of blood cultures and echocardiography. This is a pdf document titled modified dukes criteria for diagnosis of infective endocarditis. Clinical criteria for definite endocarditis requires two major criteria, or one major and three minor criteria, or five minor criteria. Clinical criteria are 2 major, 1 major plus 3 minor or 5 minor criteria e. Sexton dj, durack dt, bashore tm, corey gr, kisslo j, and the duke endocarditis service. Major criterion includes positive blood culture for typical. Antibiotic treatment of infec tious endocarditis depends on whether the involved valve is native or. Positive blood culture for typical infective endocarditis organisms s. Guidelines for the diagnosis and antibiotic treatment of. The duke criteria for endocarditis are summarized below.
According to the duke criteria, diagnosis of infective endocarditis can be definite, possible, or rejected. Click on the image or right click to open the source website in a new browser window. Infective endocarditis ie refers to infection of the endocardial surface of the heart. Echocardiographic findings consistent with endocarditis but does not meet major criteria table 2. Diagnosis of infective endocarditis uses the modified duke criteria. All 5 minor criteria the diagnosis is considered possible if 1 major and 1 minor criteria are met, or if there are 3 minor. Duke criteria for infectious endocarditis diagnosis. Minor criterion includes predisposing heart condition or iv drug use, fever, vascular phenomena, immunologic phenomena, microbiological. Value and limitations of the duke criteria for the. Many studies have now demonstrated the superiority of the duke. Diagnostic criteria and problems in infective endocarditis. Three echocardiographic findings were considered to be major criteria for the diagnosis of endocarditis.
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